Ketamine, which was first used as an anesthetic, has changed the way bipolar disorder is treated by focusing on depressive moments that other drugs don't work to improve. This drug is being used more in psychiatric situations because it works quickly and well to treat depression.
Ketamine has a different effect on mood problems compared to regular antidepressants, which work on the serotonin, norepinephrine, and dopamine processes in the brain. Ketamine mostly works through the glutamate route. Glutamate is a stimulant that changes the way synapses change and how we learn and remember things. Ketamine changes the way glutamate is sent, which makes neurons more flexible, and new connections form between neurons. This process resets the parts of the brain that control mood.
Low doses of ketamine given intravenously while a doctor watches are the usual way to treat bipolar depression. The treatment plan generally includes injections for a long time. Normal antidepressants may not start to work for weeks, but people who take this drug often feel better after the first dose.
Ketamine use needs to be managed properly. Keep in mind that a single dose may only have short-term benefits. If you don't get the right care, trouble may come back. More injections may be needed to keep the benefits going. Because it is a psychoactive drug, there are worries about dissociation effects like dreams and changes in how you see things after an injection. Because of this, training needs to be done in a controlled setting.